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Ophthalmology. 2013 Oct;120(10):2051-7. doi: 10.1016/j.ophtha.2013.03.026. Epub 2013 May 19.

The age-related maculopathy susceptibility 2 polymorphism and polypoidal choroidal vasculopathy in Asian populations: a meta-analysis.

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1
Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P. R. China.

Abstract

OBJECTIVE:

To assess the role of the age-related maculopathy susceptibility 2 (ARMS2) A69S polymorphism as a risk factor for polypoidal choroidal vasculopathy (PCV) in Asian populations.

METHODS:

We performed a meta-analysis of the association of the A69S variant with PCV in Asian populations using data available from 14 case-control studies involving 6552 subjects. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed- and random-effects models. Sensitivity analysis also was performed.

MAIN OUTCOME MEASURES:

Understanding the relationship between the A69S variant and PCV is essential to provide new insights into pathophysiology and potential targets for intervention of PCV.

RESULTS:

The pooled OR in random-effects models for genotype TG+TT versus wild homozygous genotype GG is 2.39 (95% CI, 1.98-2.89), the OR of heterozygous genotype TG versus GG is 1.66 (95% CI, 1.37-2.00), the OR of homozygous genotype TT versus GG is 4.74 (95% CI, 3.94-5.70), and the OR of allele T versus G is 2.14 (95% CI, 1.79-2.56). A sensitivity analysis indicated the robustness of our findings.

CONCLUSIONS:

Our analysis provides evidence that the A69S variant is associated with an increased risk of PCV in Asian populations. The variant of A69S could be a promising genetic biomarker of PCV.

FINANCIAL DISCLOSURE(S):

The author(s) have no proprietary or commercial interest in any materials discussed in this article.

PMID:
23697955
DOI:
10.1016/j.ophtha.2013.03.026
[Indexed for MEDLINE]
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