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Open Biol. 2013 May 22;3(5):130044. doi: 10.1098/rsob.130044.

A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli.

Author information

1
Cell and Developmental Biology, Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Aurora, CO, USA.

Abstract

Major histocompatibility class I (MHCI) molecules are well known for their immunological role in mediating tissue graft rejection. Recently, these molecules were discovered to be expressed in distinct neuronal subclasses, dispelling the long-held tenet that the uninjured brain is immune-privileged. Here, we show that MHCI molecules are expressed in the main olfactory bulb (MOB) of adult animals. Furthermore, we find that mice with diminished levels of MHCI expression have enlarged MOBs containing an increased number of small, morphologically abnormal and ectopically located P2 glomeruli. These findings suggest that MHCI molecules may play an important role in the proper formation of glomeruli in the bulb.

KEYWORDS:

P2 glomerulus; main histocompatibility complex I; main olfactory bulb; major histocompatibility class I molecules; olfaction

PMID:
23697805
PMCID:
PMC3866874
DOI:
10.1098/rsob.130044
[Indexed for MEDLINE]
Free PMC Article

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