Format

Send to

Choose Destination
Cancer Epidemiol Biomarkers Prev. 2013 Sep;22(9):1509-19. doi: 10.1158/1055-9965.EPI-13-0341. Epub 2013 May 22.

Low-fat diet and skin cancer risk: the women's health initiative randomized controlled dietary modification trial.

Author information

1
Stanford School of Medicine, Stanford University, Stanford, USA.

Abstract

BACKGROUND:

Large cohort studies have reported no relationship between dietary fat and nonmelanoma skin cancer (NMSC), although a low-fat diet intervention reduced NMSC risk in a small clinical trial. In animal studies, skin tumor development has been reduced by low-fat diet. We evaluated the effect of a low-fat dietary pattern on NMSC and melanoma in the Women's Health Initiative Dietary Modification trial.

METHODS:

Postmenopausal women aged 50 to 79 years (n = 48,835) were randomly assigned to the low-fat dietary pattern intervention (n = 19,541) or comparison group (n = 29,294). The intervention goals included decreasing fat intake to 20% or less of calories, increasing vegetable and fruit intake, and increasing grain intake. Self-reported incident NMSC (n = 4,907) and physician-adjudicated incident melanoma (n = 279) were ascertained every 6 months.

RESULTS:

Over 8.1 years of follow-up, the low-fat diet intervention did not affect overall incidence of NMSC [HR 0.98; 95% confidence interval (CI), 0.92-1.04] or melanoma (HR, 1.04; 95% CI, 0.82-1.32). In subgroup analyses of melanoma risk, baseline fat intake interacted significantly with group assignment (Pinteraction = 0.006). Among women with higher baseline fat intake, the dietary intervention significantly increased risk (HR, 1.48; 95% CI, 1.06-2.07), whereas, among women with lower baseline fat intake, the intervention tended to reduce melanoma risk (HR, 0.72; 95% CI, 0.50-1.02).

CONCLUSIONS:

In this large randomized trial, a low-fat dietary pattern did not affect overall incidence of NMSC or melanoma.

IMPACT:

A low-fat diet does not reduce incidence of NMSC, but an interaction between baseline fat intake and dietary intervention on melanoma risk warrants further investigation.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00000611.

PMID:
23697610
PMCID:
PMC3880824
DOI:
10.1158/1055-9965.EPI-13-0341
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center