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PLoS Comput Biol. 2013;9(5):e1003060. doi: 10.1371/journal.pcbi.1003060. Epub 2013 May 16.

Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation.

Author information

1
Department of Computational Genomics, CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

Abstract

Selective sweeps are at the core of adaptive evolution. We study how the shape of coalescent trees is affected by recent selective sweeps. To do so we define a coarse-grained measure of tree topology. This measure has appealing analytical properties, its distribution is derived from a uniform, and it is easy to estimate from experimental data. We show how it can be cast into a test for recent selective sweeps using microsatellite markers and present an application to an experimental data set from Plasmodium falciparum.

PMID:
23696722
PMCID:
PMC3656098
DOI:
10.1371/journal.pcbi.1003060
[Indexed for MEDLINE]
Free PMC Article

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