Format

Send to

Choose Destination
See comment in PubMed Commons below
Cancer. 2013 Aug 1;119(15):2737-46. doi: 10.1002/cncr.28029. Epub 2013 May 21.

Pathologic and gene expression features of metastatic melanomas to the brain.

Author information

1
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.

Abstract

BACKGROUND:

The prognosis of metastatic melanomas to the brain (MBM) is variable with prolonged survival in a subset. It is unclear whether MBM differ from extracranial metastases (EcM) and primary melanomas (PrM).

METHODS:

To study the biology of MBM, histopathologic analysis of tumor blocks from patients' craniotomy samples and whole-genome expression profiling (WGEP) with confirmatory immunohistochemistry were performed.

RESULTS:

High mononuclear infiltrate and low intratumoral hemorrhage were associated with prolonged overall survival (OS). Pathway analysis of WGEP data from 29 such craniotomy tumor blocks demonstrated that several immune-related BioCarta gene sets were associated with prolonged OS. WGEP analysis of MBM in comparison with same-patient EcM and PrM showed that MBM and EcM were similar, but both differ significantly from PrM. Immunohistochemical analysis revealed that peritumoral CD3⁺ and CD8⁺ cells were associated with prolonged OS.

CONCLUSIONS:

MBMs are more similar to EcM compared with PrM. Immune infiltrate is a favorable prognostic factor for MBM.

KEYWORDS:

brain metastases; craniotomy immune infiltrate; gene expression profiling; melanoma

PMID:
23695963
PMCID:
PMC3901051
DOI:
10.1002/cncr.28029
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center