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Neurol Sci. 2013 May;34 Suppl 1:S57-60. doi: 10.1007/s10072-013-1377-x.

Chronification of migraine: what clinical strategies to combat it?

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Department of Clinical and Experimental Medicine, University Hospital, University of Parma, Padiglione Barbieri, 3° piano, Via Gramsci, 14, 43126 Parma, Italy.


Once migraine becomes chronic and has transformed into a form of headache that occurs daily or almost, the treatment options available are few and complex. This makes it important to take action before this point is reached, using all the measures that can be obtained from our current knowledge of chronic migraine (or transformed migraine) on the one hand, and on the potential factors of chronification (or transformation) on the other. Therefore, in order to reduce the risk of migraine chronification, it would appear important to: (a) administer suitable preventive treatments for subjects who have been suffering from migraines ≥4 days a month for ≥3 months; (b) take special care not to overuse symptomatic medications, particularly when they contain substances with a sedative effect; and (c) investigate the concomitant presence of depression, hypertension and excess weight and administer appropriate treatment when present.

[Indexed for MEDLINE]

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