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J Neuroimmunol. 2013 Jul 15;260(1-2):9-16. doi: 10.1016/j.jneuroim.2013.04.019. Epub 2013 May 17.

The neuropeptides α-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells.

Author information

1
Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA.

Abstract

Within the immunosuppressive ocular microenvironment, there are constitutively present the immunomodulating neuropeptides alpha-melanocyte stimulating hormone (α-MSH) and neuropeptide Y (NPY) that promote suppressor functionality in macrophages. In this study, we examined the possibility that α-MSH and NPY modulate phagocytic activity in macrophages. The macrophages treated with α-MSH and NPY were significantly suppressed in their capacity to phagocytize unopsonized Escherichia coli and Staphylococcus aureus bioparticles, but not antibody-opsonized bioparticles. The neuropeptides significantly suppressed phagolysosome activation, and the FcR-associated generation of reactive oxidative species as well. This suppression corresponds to neuropeptide modulation of macrophage functionality within the ocular microenvironment to suppress the activation of immunogenic inflammation.

PMID:
23689030
PMCID:
PMC3679250
DOI:
10.1016/j.jneuroim.2013.04.019
[Indexed for MEDLINE]
Free PMC Article

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