Format

Send to

Choose Destination
See comment in PubMed Commons below
Ageing Res Rev. 2013 Sep;12(4):1024-41. doi: 10.1016/j.arr.2013.05.003. Epub 2013 May 17.

Epigenetic mechanisms in Alzheimer's disease: implications for pathogenesis and therapy.

Author information

1
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.

Abstract

The vast majority of Alzheimer's disease (AD) are late-onset forms (LOAD) likely due to the interplay of environmental influences and individual genetic susceptibility. Epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNAs, constitute dynamic intracellular processes for translating environmental stimuli into modifications in gene expression. Over the past decade it has become increasingly clear that epigenetic mechanisms play a pivotal role in aging the pathogenesis of AD. Here, we provide a review of the major mechanisms for epigenetic modification and how they are reportedly altered in aging and AD. Moreover, we also consider how aberrant epigenetic modifications may lead to AD pathogenesis, and we review the therapeutic potential of epigenetic treatments for AD.

KEYWORDS:

Aging; Alzheimer's disease; Epigenetics; Pathogenesis; Therapy

PMID:
23688931
DOI:
10.1016/j.arr.2013.05.003
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center