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Curr Opin Immunol. 2013 Jun;25(3):366-72. doi: 10.1016/j.coi.2013.04.003. Epub 2013 May 18.

Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells.

Author information

1
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, United States.

Abstract

Our bodies are continuously exposed to various types of infectious pathogens. Vaccinations are the most cost effective way to protect our bodies against a variety of infectious microbes. The efficacy of most vaccines relies on protective antibody production and generation of memory B cells. These two key components develop mostly from B cells that participate in germinal center reactions. Recent efforts have highlighted the critical role of follicular helper CD4 T (Tfh) cells in the generation of germinal centers. Given that Bcl6 is a major transcription factor for Tfh differentiation, here we review recent developments in the understanding of signaling molecules that regulate Bcl6 expression in CD4 T cells, as a potential target for development of more efficacious vaccines.

PMID:
23688737
PMCID:
PMC3763739
DOI:
10.1016/j.coi.2013.04.003
[Indexed for MEDLINE]
Free PMC Article

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