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Int J Antimicrob Agents. 2013 Jul;42(1):83-6. doi: 10.1016/j.ijantimicag.2013.04.014. Epub 2013 May 18.

Multidrug-resistant tet(X)-containing hospital isolates in Sierra Leone.

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Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC, USA.


The tet(X) gene encodes a flavin-dependent monooxygenase that confers resistance to all clinically relevant tetracycline antibiotics including tigecycline. It has only previously been identified in environmental and non-human pathogenic bacteria. To investigate levels of multidrug resistance in Bo, Sierra Leone, a molecular epidemiological study was conducted using an antimicrobial resistance determinant microarray (ARDM), PCR and DNA sequencing. The study found that 21% of isolates from Mercy Hospital (Bo, Sierra Leone) were tet(X)-positive, all of which originated from urinary specimens. Use of molecular epidemiological surveillance tools has provided the first evidence of tet(X)-containing multidrug-resistant Gram-negative hospital isolates in a hospital in Sierra Leone.

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