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Org Lett. 2013 Jun 7;15(11):2648-51. doi: 10.1021/ol4009377. Epub 2013 May 20.

Catalytic decarboxylative fluorination for the synthesis of tri- and difluoromethyl arenes.

Author information

1
Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

Abstract

Treatment of readily available α,α-difluoro- and α-fluoroarylacetic acids with Selectfluor under Ag(I) catalysis led to decarboxylative fluorination. This operationally simple reaction gave access to tri- and difluoromethylarenes applying a late-stage fluorination strategy. Translation to [(18)F]labeling is demonstrated using [(18)F]Selectfluor bis(triflate), a reagent affording [(18)F]tri- and [(18)F]difluoromethylarenes not within reach with [(18)F]F2.

PMID:
23687958
DOI:
10.1021/ol4009377
[Indexed for MEDLINE]

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