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J Pediatric Infect Dis Soc. 2012 Sep;1(3):244-9. doi: 10.1093/jpids/pis065. Epub 2012 Jul 3.

Nevirapine-Resistant HIV-1 DNA in Breast Milk After Single-Dose Nevirapine With or Without Zidovudine for Prevention of Mother-to-Child Transmission.

Author information

1
Departments of Pediatrics Seattle Children's Hospital Research Institute, Center for Childhood Infections.
2
Seattle Children's Hospital Research Institute, Center for Childhood Infections.
3
Global Health, and Health Alliance International, Seattle, Washington.
4
Health Alliance International, Seattle, Washington.
5
Mozambique Ministry of Health, Maputo.
6
Departments of Pediatrics Laboratory Medicine, University of Washington Seattle Children's Hospital Research Institute, Center for Childhood Infections.

Abstract

Among 30 human immunodeficiency virus type 1 (HIV-1)-infected women who received single-dose nevirapine (NVP), 17 (57%) had NVP-resistant HIV-1 detected in breast milk. NVP resistance in breast milk persisted for at least 8 months postpartum and was apparently transmitted to at least 1 infant. NVP resistance was detected less often in women who also received zidovudine.

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