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World J Gastroenterol. 2013 May 14;19(18):2806-10. doi: 10.3748/wjg.v19.i18.2806.

Extremely high prevalence of Helicobacter pylori infection in Bhutan.

Author information

1
Ratha-korn Vilaichone, Gastroenterology Unit, Department of Medicine, Thammasat University Hospital, Pathumthani 12120, Thailand.

Abstract

AIM:

To revealed the prevalence of Helicobacter pylori (H. pylori) infection in the Bhutanese population.

METHODS:

We recruited a total of 372 volunteers (214 females and 158 males; mean age of 39.6 ± 14.9 years) from three Bhutanese cities (Thimphu, Punaka, and Wangdue). The status of H. pylori infection was determined based on five different tests: the rapid urease test (CLO test), culture, histology, immunohistochemistry (IHC), and serum anti H. pylori-antibody.

RESULTS:

The serological test showed a significantly higher positive rate compared with the CLO test, culture, histology and IHC (P < 0.001, P < 0.001, P = 0.01, and P = 0.01, respectively). When the subjects were considered to be H. pylori positive in the case of at least one test showing a positive result, the overall prevalence of H. pylori infection in Bhutan was 73.4%. The prevalence of H. pylori infection significantly decreased with age (P < 0.01). The prevalence of H. pylori infection was lower in Thimphu than in Punakha and Wangdue (P = 0.001 and 0.06, respectively). The prevalence of H. pylori infection was significantly higher in patients with peptic ulcers than in those with gastritis (91.4% vs 71.3%, P = 0.003).

CONCLUSION:

The high incidence of gastric cancer in Bhutan may be attributed to the high prevalence of H. pylori infection.

KEYWORDS:

Bhutan; Helicobacter pylori; Prevalence

PMID:
23687418
PMCID:
PMC3653155
DOI:
10.3748/wjg.v19.i18.2806
[Indexed for MEDLINE]
Free PMC Article
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