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Anesth Analg. 2013 Jul;117(1):61-4. doi: 10.1213/ANE.0b013e318292cbd0. Epub 2013 May 17.

Case report: profound hypotension after anesthetic induction with propofol in patients treated with rifampin.

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Department of Anesthesia and Critical Care, Massachusetts General Hospital, GRJ-4-416, 55 Fruit St., Boston, MA 02114-2696, USA.


Rifampin is commonly used for the treatment of tuberculosis and staphylococcal infections, as well as for prevention of infection in cardiac valve and bone surgeries. We report a case of profound hypotension after anesthesia induction with propofol in a patient who was treated with two 600 mg doses of rifampin for prophylaxis of infection before surgery. In a retrospective case-control study of 75 patients, we confirmed this potentially serious drug-drug interaction. After rifampin, there was a significant and prolonged arterial blood pressure reduction when patients received propofol, but not thiopental.

[Indexed for MEDLINE]

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