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Oncogene. 2014 Apr 24;33(17):2236-44. doi: 10.1038/onc.2013.168. Epub 2013 May 20.

The pleiotrophin-ALK axis is required for tumorigenicity of glioblastoma stem cells.

Author information

1
Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
2
Laboratory of Genome Structure and Function, Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
3
Department of Neurosurgery, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.

Abstract

Increasing evidence suggests that brain tumors arise from the transformation of neural stem/precursor/progenitor cells. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma. Here we show that anaplastic lymphoma kinase (ALK) and its ligand pleiotrophin are required for the self-renewal and tumorigenicity of glioblastoma stem cells (GSCs). Furthermore, we demonstrate that pleiotrophin is transactivated directly by SOX2, a transcription factor essential for the maintenance of both neural stem cells and GSCs. We speculate that the pleiotrophin-ALK axis may be a promising target for the therapy of glioblastoma.

PMID:
23686309
DOI:
10.1038/onc.2013.168
[Indexed for MEDLINE]

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