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Curr Top Microbiol Immunol. 2013;371:67-104. doi: 10.1007/978-3-642-37765-5_3.

The antiviral activities of tetherin.

Author information

1
Department of Infectious Disease, King's College London School of Medicine, London, UK. stuart.neil@kcl.ac.uk

Abstract

Tetherin (BST2/CD317) has emerged as a key host cell defense molecule, inhibiting the release and spread of diverse enveloped virions from infected cells. In this chapter, I review the molecular and cellular basis for tetherin's antiviral activities and the function of virally encoded countermeasures that disrupt its function. I further describe recent advances in our understanding of tetherin's associated role in viral pattern recognition and the evidence for its role in limiting viral pathogenesis in vivo.

PMID:
23686232
DOI:
10.1007/978-3-642-37765-5_3
[Indexed for MEDLINE]

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