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Fitoterapia. 2013 Sep;89:167-74. doi: 10.1016/j.fitote.2013.05.008. Epub 2013 May 15.

Phenylethanoid glycosides with anti-inflammatory activities from the stems of Cistanche deserticola cultured in Tarim desert.

Author information

1
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.

Abstract

Five new phenylethanoid glycosides, cistanosides J-N (1-5), together with 15 known ones (6-20) were isolated from the stems of Cistanche deserticola cultured in Tarim desert, China. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR) and chemical degradation. All the compounds obtained were examined for their inhibitory effect on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse microglial cells (BV-2 cells), and compounds 2 and 8 showed potent inhibition on the NO production with IC50 values of 14.94 μM and 14.32 μM, respectively.

KEYWORDS:

Anti-inflammatory activity; Cistanche deserticola; Cistanoside; Phenylethanoid glycoside

PMID:
23685247
DOI:
10.1016/j.fitote.2013.05.008
[Indexed for MEDLINE]

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