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Eur J Paediatr Neurol. 2013 Sep;17(5):429-36. doi: 10.1016/j.ejpn.2013.03.005. Epub 2013 May 16.

Isolated paediatric neurosarcoidosis presenting as epilepsia partialis continua: a case report and review of literature.

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Department of Paediatric Neurology, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK.


Isolated paediatric neurosarcoidosis (IPN) is exceptionally rare and only seven cases have been reported so far in the literature. We report the clinical and radiological profile of a 7 year-old boy with epilepsia partialis continua (EPC) who was initially thought to have Acute Disseminated Encephalomyelitis (ADEM), but was subsequently found to have isolated neurosarcoidosis. Additionally, we performed a literature search on Medline and Embase and secondary sources of data such as reference list of articles reviewed. Whilst cranial neuropathy is the commonest presenting feature in adults with neurosarcoidosis, paediatric patients are more likely to present with seizures. Diagnosis presents a clinical challenge as a result of its protean manifestations. Due to its rarity, there remains a lack of evidence base to inform the best choice of treatment for these children. Our patient was successfully treated with a combination of various immunomodulants.


Child; Epilepsia partialis continua; Neurosarcoidosis

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