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Bioorg Med Chem Lett. 2013 Jul 1;23(13):3884-6. doi: 10.1016/j.bmcl.2013.04.066. Epub 2013 May 3.

Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor.

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1
Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan.

Abstract

USP7, a deubiquitylating enzyme hydrolyzing the isopeptide bond at the C-terminus of ubiquitin, is an emerging cancer target. We isolated spongiacidin C from the marine sponge Stylissa massa as the first USP7 inhibitor from a natural source. This compound inhibited USP7 most strongly with an IC50 of 3.8 μM among several USP family members tested.

PMID:
23684893
DOI:
10.1016/j.bmcl.2013.04.066
[Indexed for MEDLINE]
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