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Mol Cell Endocrinol. 2013 Aug 15;375(1-2):10-3. doi: 10.1016/j.mce.2013.05.005. Epub 2013 May 16.

Fifty years ago: the quest for steroid hormone receptors.

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1
de Duve Institute and Université Catholique de Louvain, Brussels, Belgium. guy.rousseau@uclouvain.be

Erratum in

  • Mol Cell Endocrinol. 2014 Mar 5;383(1-2):214.

Abstract

In 1963 Peter Karlson put forward the revolutionary "hormone-gene" hypothesis, which would change drastically the way in which steroid hormones were thought to act at the time. From a historical perspective, this review relates the acceptance of this initially controversial idea, the discovery of the steroid receptors and the key experiments that have led to the current understanding of the mechanism of steroid hormone action. It shows how, over 50years, the field has widened beyond all expectation and has contributed to major advances not only in endocrinology, but also in molecular biology, pharmacology and therapeutics.

PMID:
23684885
DOI:
10.1016/j.mce.2013.05.005
[Indexed for MEDLINE]
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