Format

Send to

Choose Destination
J Biomater Sci Polym Ed. 2013;24(9):1041-56. doi: 10.1080/09205063.2012.735097. Epub 2012 Oct 31.

Synthesis of macroporous poly(dimethylsiloxane) scaffolds for tissue engineering applications.

Author information

1
Department of Biomedical Engineering, College of Engineering, University of Miami, Coral Gables, FL 33134, USA.

Abstract

Macroporous, biostable scaffolds with controlled porous architecture were prepared from poly(dimethylsiloxane) (PDMS) using sodium chloride particles and a solvent casting and particulate leaching technique. The effect of particulate size range and overall porosity on the resulting structure was evaluated. Results found 90% v/v scaffolds and particulate ranges above 100 μm to have the most optimal open framework and porosity. Resulting hydrophobic PDMS scaffolds were coated with fibronectin and evaluated as a platform for adherent cell culture using human mesenchymal stem cells. Biocompatibility of PDMS scaffolds was also evaluated in a rodent model, where implants were found to be highly biocompatible and biostable, with positive extracellular matrix deposition throughout the scaffold. These results demonstrate the suitability of macroporous PDMS scaffolds for tissue engineering applications where strong integration with the host is desired.

PMID:
23683037
PMCID:
PMC4437734
DOI:
10.1080/09205063.2012.735097
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center