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Elife. 2013 May 14;2:e00422. doi: 10.7554/eLife.00422.

ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast.

Author information

1
Department of Molecular and Cellular Biology , University of California, Davis , Davis , United States.

Abstract

Mitochondrial division is important for mitochondrial distribution and function. Recent data have demonstrated that ER-mitochondria contacts mark mitochondrial division sites, but the molecular basis and functions of these contacts are not understood. Here we show that in yeast, the ER-mitochondria tethering complex, ERMES, and the highly conserved Miro GTPase, Gem1, are spatially and functionally linked to ER-associated mitochondrial division. Gem1 acts as a negative regulator of ER-mitochondria contacts, an activity required for the spatial resolution and distribution of newly generated mitochondrial tips following division. Previous data have demonstrated that ERMES localizes with a subset of actively replicating mitochondrial nucleoids. We show that mitochondrial division is spatially linked to nucleoids and that a majority of these nucleoids segregate prior to division, resulting in their distribution into newly generated tips in the mitochondrial network. Thus, we postulate that ER-associated division serves to link the distribution of mitochondria and mitochondrial nucleoids in cells. DOI:http://dx.doi.org/10.7554/eLife.00422.001.

KEYWORDS:

ERMES; Gem1; Miro; S. cerevisiae; mitochondria; mitochondrial DNA

Comment in

PMID:
23682313
PMCID:
PMC3654481
DOI:
10.7554/eLife.00422
[Indexed for MEDLINE]
Free PMC Article
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