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Bioinformatics. 2013 Jul 15;29(14):1750-7. doi: 10.1093/bioinformatics/btt278. Epub 2013 May 15.

CAPITO--a web server-based analysis and plotting tool for circular dichroism data.

Author information

1
Biomolecular NMR Spectroscopy, Leibniz Institute for Age Research-Fritz Lipmann Institute, Beutenbergstr. 11, 07745 Jena, Germany. cwiede@fli-leibniz.de

Abstract

MOTIVATION:

Circular dichroism (CD) spectroscopy is one of the most versatile tools to study protein folding and to validate the proper fold of purified proteins. Here, we aim to provide a readily accessible, user-friendly and platform-independent tool capable of analysing multiple CD datasets of virtually any format and returning results as high-quality graphical output to the user.

RESULTS:

CAPITO (CD Anaylsis and Plotting Tool) is a novel web server-based tool for analysing and plotting CD data. It allows reliable estimation of secondary structure content utilizing different approaches. CAPITO accepts multiple CD datasets and, hence, is well suited for a wide application range such as the analysis of temperature or pH-dependent (un)folding and the comparison of mutants.

AVAILABILITY:

http://capito.nmr.fli-leibniz.de.

CONTACT:

cwiede@fli-leibniz.de or mago@fli-leibniz.de

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

PMID:
23681122
DOI:
10.1093/bioinformatics/btt278
[Indexed for MEDLINE]

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