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Infect Genet Evol. 2013 Aug;18:284-6. doi: 10.1016/j.meegid.2013.05.003. Epub 2013 May 13.

Limited intra-genetic diversity in Dientamoeba fragilis housekeeping genes.

Author information

1
Laboratory of Parasitology, Department of Microbiology and Infection Control, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. run@ssi.dk

Abstract

Dientamoeba fragilis is a common intestinal parasite of unsettled clinical significance. Differences in clinical outcome of parasitic infections may reflect parasite genetic diversity, and so tools to study intra-genetic diversity that could potentially reflect differences in clinical phenotypes are warranted. Here, we show that genetic analysis of three D. fragilis housekeeping genes enables clear distinction between the two known genotypes, but that integration of housekeeping genes in multi-locus sequencing tools for D. fragilis may have limited epidemiological and clinical value due to no further added genetic resolution.

KEYWORDS:

Actin; Dientamoeba; Elongation factor; Genetic diversity; Molecular epidemiology; Multilocus sequence typing

PMID:
23681023
DOI:
10.1016/j.meegid.2013.05.003
[Indexed for MEDLINE]
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