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Int J Mol Sci. 2013 May 16;14(5):10307-31. doi: 10.3390/ijms140510307.

Methylated DNA and microRNA in body fluids as biomarkers for cancer detection.

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1
Laboratory of Cancer Biology, Department of Medical Oncology, Institute of Clinical Science, Sir Runrun Shaw Hospital, Medical School of Zhejiang University, Hangzhou 310029, China. jinhc@zju.edu.cn.

Abstract

Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. After the identification of circulating cell-free nuclear acids, increasing evidence demonstrated great potential of cell-free epigenetic biomarkers in the blood or other body fluids for cancer detection.

PMID:
23681012
PMCID:
PMC3676840
DOI:
10.3390/ijms140510307
[Indexed for MEDLINE]
Free PMC Article
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