Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Pharm. 2013 Aug 16;452(1-2):241-8. doi: 10.1016/j.ijpharm.2013.05.011. Epub 2013 May 13.

Gastro-floating tablets of cephalexin: preparation and in vitro/in vivo evaluation.

Author information

1
Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China.

Abstract

Gastro-floating tablets of cephalexin were developed to prolong the residence time in major absorption sites. Gastro-floating tablets were prepared and optimized using hydroxypropyl methylcellulose (HPMC K100M) as matrix and sodium bicarbonate as a gas-forming agent. The properties of the tablets in terms of floating lag time, floating time and in vitro release were evaluated. Furthermore, in vivo pharmacokinetic study in fed and fasted beagle dogs was performed. The gastro-floating tablets had short floating lag time and exhibited a satisfactory sustained-release profile in vitro. Compared with conventional capsules, the gastro-floating tablets presented a sustained-release behavior with a relative bioavailability of 99.4%, while the reference sustained-release tablets gave a relative bioavailability of only 39.3%. Meanwhile, the food had significant effect on the pharmacokinetics of sustained-release tablets. It was concluded that the gastro-floating tablets had a sustained-release effect in vitro and in vivo, as well as desired pharmacokinetic properties in both fed and fasted conditions.

PMID:
23680730
DOI:
10.1016/j.ijpharm.2013.05.011
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center