Format

Send to

Choose Destination
Biol Blood Marrow Transplant. 2013 Aug;19(8):1220-6. doi: 10.1016/j.bbmt.2013.05.005. Epub 2013 May 13.

Mortality rates of human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic cell transplantation recipients.

Author information

1
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Abstract

Human metapneumovirus (HMPV), a common respiratory virus, can cause severe disease in pre- and post-hematopoietic cell transplantation (HCT) recipients. We conducted a retrospective cohort analysis in HCT patients with HMPV (n = 23) or respiratory syncytial virus (n = 23) detected in bronchoalveolar lavage samples by reverse transcription PCR between 2006 and 2011 to determine disease characteristics and factors associated with outcome. Mortality rates at 100 days were 43% for both HMPV and respiratory syncytial virus lower respiratory tract disease. Steroid therapy, oxygen requirement >2 L or mechanical ventilation, and bone marrow as cell source were significant risk factors for overall and virus-related mortality in multivariable models, whereas the virus type was not. The presence of centrilobular/nodular radiographic infiltrates was a possible protective factor for mechanical ventilation. Thus, HMPV lower respiratory tract disease is associated with high mortality in HCT recipients. Earlier detection in combination with new antiviral therapy is needed to reduce mortality among HCT recipients.

KEYWORDS:

Hematopoietic stem cell transplant; Human metapneumovirus; Immunocompromised; Pneumonia; Respiratory syncytial virus

Comment in

PMID:
23680472
PMCID:
PMC3752411
DOI:
10.1016/j.bbmt.2013.05.005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center