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J Affect Disord. 2013 Sep 5;150(2):261-5. doi: 10.1016/j.jad.2013.04.004. Epub 2013 May 13.

Association of genetic variation in CACNA1C with bipolar disorder in Han Chinese.

Author information

1
Department of Psychiatry, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Abstract

BACKGROUND:

A growing body of evidence highlights the existence of shared genetic susceptibility to both major depressive disorder (MDD) and bipolar disorder (BD), suggesting some potential genetic overlap between the disorders. Genome-wide association studies have identified consistent association of single nucleotide polymorphisms of the α-1 C subunit of the L-type voltage-gated calcium channel gene (CACNA1C) with MDD and BD, suggesting CACNA1C as a promising candidate gene for susceptibility to mood disorders. In the present study, we tested the association of CACNA1C with MDD and BD in Han Chinese.

METHODS:

We genotyped three potentially functional polymorphisms in 635 MDD patients, 286 BD patients and 730 normal, control patients.

RESULTS:

The genotype frequencies of SNP rs1051375 showed statistically significant differences between the BD and control groups (P=0.005). At the allele level, the difference of G allele frequency of rs1051375 between BD patients and control subjects was also significant (P=0.011; OR=1.30, 95% CI: 1.06-1.58). We found that GG genotype of rs1051375 carriers had a lower age at onset than those with the AG or AA genotype, and the mean±standard deviation ages at onset of GG, AG and AA carriers were 24.04±4.22, 25.76±4.75 and 25.78±4.33 years, respectively. Neither genotype nor allele frequencies of the three polymorphisms were found to be significantly different between the MDD patients and control subjects.

LIMITATIONS:

The relative small sample size in BD group should be considered a limitation of this study.

CONCLUSIONS:

Our initial findings support a potential association of CACNA1C as a genetic risk factor for BD susceptibility.

KEYWORDS:

Age at onset; Bipolar disorder; CACNA1C; Major depressive disorder; Polymorphism

PMID:
23680436
DOI:
10.1016/j.jad.2013.04.004
[Indexed for MEDLINE]

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