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Oral Dis. 2014 May;20(4):359-66. doi: 10.1111/odi.12125. Epub 2013 May 16.

Aggravation of inflammatory bowel diseases by oral streptococci.

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1
Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.

Abstract

OBJECTIVES:

Streptococcus mutans can aggravate colitis in mice. We evaluated the virulence of colitis using type strains as well as blood isolates of several oral streptococcal species.

MATERIALS AND METHODS:

We investigated the susceptibility of blood isolates of several oral streptococci to phagocytosis, adhesion to and invasion of hepatic cells and interferon-γ secretion. A mouse model of dextran sodium sulphate-induced colitis was used to evaluate bacterial aggravation of colitis. In addition, interferon-γ antibody was administered to mice with prominent aggravation of colitis.

RESULTS:

In vitro analyses showed that Streptococcus sanguinis ATCC 10556 was a possible virulent strain among type strains of several oral streptococci, and that analysis of blood isolates of S. sanguinis TW289 revealed a potential virulent strain. Intravenous administration of ATCC 10556 and TW289 caused prominent aggravation of dextran sodium sulphate-induced colitis, and histopathological examinations showed that interferon-γ secretion due to infection of hepatic cells caused colitis aggravation. Administration of interferon-γ antibody suppressed TW289-induced colitis.

CONCLUSION:

These results suggest that some virulent oral streptococcal strains are associated with the aggravation of colitis induced by enhanced secretion of interferon-γ when they invade the bloodstream.

KEYWORDS:

bacteraemia; inflammatory bowel diseases; interferon-gamma; liver; oral streptococci

PMID:
23679203
DOI:
10.1111/odi.12125
[Indexed for MEDLINE]
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