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Eur J Neurol. 2014;21(1):28-33. doi: 10.1111/ene.12190. Epub 2013 May 17.

Epidemiology of chronic inflammatory neuropathies in southeast England.

Author information

1
Department of Clinical Neuroscience, King's College London, London, UK.

Abstract

BACKGROUND AND PURPOSE:

There is little information about the prevalence and disease burden of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and paraproteinaemic demyelinating neuropathy (PDN).

METHODS:

Multiple sources were used to study the prevalence and clinical features of these diseases in a southeast England population of 3,557,352 people.

RESULTS:

The crude prevalences were as follows: CIDP, 2.84 (95% CI 2.31-3.45); MMN, 0.53 (95% CI 0.32-0.83); and PDN, 1.04 (95% CI 0.73-1.43) per 100,000 population. All three diseases were more common in men than in women. The peak decade of onset was older in those with CIDP (70-79 years) and PDN (70-79 years) than in those with MMN (50-59 years). Disability was greater in CIDP and PDN, with median (range) overall neuropathy limitations scores of 4 (0-8) and 4 (1-6), respectively, than in MMN, with a score of 2 (1-5).

CONCLUSION:

The common forms of chronic inflammatory neuropathy cause a considerable disease burden in the community.

KEYWORDS:

chronic inflammatory demyelinating polyradiculoneuropathy; disability; epidemiology; multifocal motor neuropathy; paraproteinaemic demyelinating neuropathy

PMID:
23679015
DOI:
10.1111/ene.12190
[Indexed for MEDLINE]

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