Format

Send to

Choose Destination
See comment in PubMed Commons below
J Am Chem Soc. 2013 Jun 12;135(23):8480-3. doi: 10.1021/ja4032677. Epub 2013 May 28.

Sterically controlled, palladium-catalyzed intermolecular amination of arenes.

Author information

1
Department of Chemistry, University of California, Berkeley, California 94720-1460, USA.

Abstract

We report the Pd-catalyzed amination of arenes to form N-aryl phthalimides with regioselectivity controlled predominantly by steric effects. Mono-, di-, and trisubstituted arenes lacking a directing group undergo amination reactions with moderate to high yields and high regioselectivities from sequential addition of PhI(OAc)2 as an oxidant in the presence of Pd(OAc)2 as catalyst. This sterically derived selectivity contrasts that for analogous arene acetoxylation.

PMID:
23678959
DOI:
10.1021/ja4032677
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center