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Eur J Neurol. 2013 Sep;20(9):1297-304. doi: 10.1111/ene.12186. Epub 2013 May 17.

Neuropsychological course of voltage-gated potassium channel and glutamic acid decarboxylase antibody related limbic encephalitis.

Author information

1
Department of Epileptology, University of Bonn Medical Center, Bonn, Germany. christian_frisch@gmx.de

Abstract

BACKGROUND AND PURPOSE:

Autoantibodies (abs) to glutamic acid decarboxylase (GAD) and to voltage-gated potassium channels (VGKC) induce distinct courses of limbic encephalitis, related to MRI findings, seizure outcome and cognition.

METHODS:

A detailed analysis of the cognitive course of the two forms is presented, spanning a median time interval of 28 months, including parameters of attention, learning and memory in 15 VGKC-ab-positive and 16 GAD-ab-positive patients.

RESULTS:

In both groups, the initially significantly impaired attention performance recovered to a putatively premorbid level. In VGKC patients the partially severely impaired learning and memory performance improved under treatment but remained subnormal at last follow-up. By contrast, GAD-ab-positive patients had initially less impaired learning and memory scores but did not show an improvement under treatment.

CONCLUSIONS:

The results provide evidence of distinct relations between inductive processes and cognitive outcome in VGKC-ab-positive and GAD-ab-positive subforms of limbic encephalitis, which possibly depend on differences in pathogenic molecular mechanisms and affected cerebral loci.

KEYWORDS:

attention; epilepsy; limbic encephalitis subforms; long term; memory

PMID:
23678940
DOI:
10.1111/ene.12186
[Indexed for MEDLINE]

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