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Bioimpacts. 2011;1(3):189-91. doi: 10.5681/bi.2011.026. Epub 2011 Sep 30.

Microsurgeon Hirudo medicinalis as a Natural Bioshuttle for Spontaneous Mass Vaccination against Influenza A Virus.

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1
Research Center for Pharmaceutical Nanotechnology, School of Advanced Biomedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran ; Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Milan, Italy.

Abstract

INTRODUCTION:

Recent report on existence of a stem region of hemagglutinin has arisen new hopes for vaccination of influenza A as it consist of a conserve fusion peptide shared across several influenza subtypes and can be targeted by human immune system.

METHODS:

Given that traditional vaccination based on live attenuated viruses often fails to surpass such viral infection, a great deal of attention has been devoted to develop a safe yet efficient system for vaccination influenza A. We believe that a natural bioshuttle can be recruited for spontaneous mass vaccination.

RESULTS:

Thus, here, we hypothesize that a bioengineered transgenic Hirudo medicinalis can be considered as an alive bioshuttle for in-situ vaccination against influenza A virus. By introducing the designated gene(s) encoding the target fragment (i.e., stem region of hemagglutinin), this microsurgeon can act as a rapid microproducer of viral proteins for in-house mass vaccination through imparting the necessary proteins such as those, naturally presented in leech's saliva.

CONCLUSION:

This peculiar bioshuttle can be easily exploited as a medical modality choice at home resulting in greater patient compliance.

KEYWORDS:

Hirudo medicinalis; Influenza A Virus; Vaccination

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