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Small. 2013 Oct 25;9(20):3374-84. doi: 10.1002/smll.201300020. Epub 2013 May 16.

Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting.

Author information

1
Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Abstract

Fertilization is central to the survival and propagation of a species, however, the precise mechanisms that regulate the sperm's journey to the egg are not well understood. In nature, the sperm has to swim through the cervical mucus, akin to a microfluidic channel. Inspired by this, a simple, cost-effective microfluidic channel is designed on the same scale. The experimental results are supported by a computational model incorporating the exhaustion time of sperm.

KEYWORDS:

biodesign; fertility; microfluidic sorting; sperm exhaustion; sperm sorting

PMID:
23677651
PMCID:
PMC3821799
DOI:
10.1002/smll.201300020
[Indexed for MEDLINE]
Free PMC Article

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