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Pediatr Radiol. 2013 Oct;43(10):1400-3. doi: 10.1007/s00247-013-2661-x. Epub 2013 May 16.

Transient ischemic attack-like episodes without stroke-like lesions in MELAS.

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1
Division of Neurology, Kanagawa Children's Medical Center, Mutsukawa 2-138-4, Minami-ku, Yokohama, Kanagawa, 232-8555, Japan.

Abstract

A stroke-like episode is a core symptom in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Proton magnetic resonance spectroscopy (1H-MRS) is useful in the diagnosis of mitochondrial diseases. We report an 8-year-old girl with MELAS, presenting with a seizure and blindness. 1H-MRS showed a strikingly elevated lactate peak in the right occipital region, where no abnormal signals appeared on either T2-W or diffusion-weighted MRI. She recovered completely within a day. We describe this mild clinical condition with abnormal lactate peak in normal-appearing gray matter as a transient ischemic attack-like episode in MELAS.

PMID:
23677422
DOI:
10.1007/s00247-013-2661-x
[Indexed for MEDLINE]
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