Format

Send to

Choose Destination
Front Microbiol. 2013 May 14;4:96. doi: 10.3389/fmicb.2013.00096. eCollection 2013.

A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota.

Author information

1
Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science Oslo, Norway.

Abstract

The discovery and introduction of antimicrobial agents to clinical medicine was one of the greatest medical triumphs of the 20th century that revolutionized the treatment of bacterial infections. However, the gradual emergence of populations of antimicrobial-resistant pathogenic bacteria resulting from use, misuse, and abuse of antimicrobials has today become a major global health concern. Antimicrobial resistance (AMR) genes have been suggested to originate from environmental bacteria, as clinically relevant resistance genes have been detected on the chromosome of environmental bacteria. As only a few new antimicrobials have been developed in the last decade, the further evolution of resistance poses a serious threat to public health. Urgent measures are required not only to minimize the use of antimicrobials for prophylactic and therapeutic purposes but also to look for alternative strategies for the control of bacterial infections. This review examines the global picture of antimicrobial resistance, factors that favor its spread, strategies, and limitations for its control and the need for continuous training of all stake-holders i.e., medical, veterinary, public health, and other relevant professionals as well as human consumers, in the appropriate use of antimicrobial drugs.

KEYWORDS:

antimicrobial resistance; environment; human and veterinary medicine; resistance genes; soil; wastewater

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center