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Int J Biomed Sci. 2012 Dec;8(4):258-63.

(31)P and (1)h nuclear magnetic resonance spectroscopy of blood plasma in female patients with preeclampsia.

Author information

1
Department of Nuclear Medicine, University of Cologne, Cologne, Germany;

Abstract

OBJECTIVE:

Using (31)P and (1)H magnetic resonance spectroscopy to measure phosphorus- and hydrogen-containing metabolites, this study aimes to investigate whether or not women with preeclampsia have detectable systemic abnormalities concerning certain components of the blood plasma.

METHODS:

PLASMA WAS OBTAINED FROM TWO GROUPS OF WOMEN: Group 1 with preeclampsia (n=10) and Group 2, as a control group with no complications during pregnancy (n=10). Plasma analysis were performed using in-vitro (31)P and (1)H nuclear magnetic resonance spectroscopy.

RESULTS:

(31)P nuclear magnetic resonance (NMR) spectra showed significantly higher levels of lysophosphatidylcholine 1 in the plasma of the patients in Group 1, along with significantly decreased levels of lysophosphatidylcholine 2 and phosphatidylinositol. However, the total amount of phospholipids did not differ significantly between the groups. In addition, the (1)H NMR spectra showed a significantly lower level of HDL in samples from Group 1, and a trend towards higher plasma levels of VLDL 2 and LDL 2 in the same group.

CONCLUSION:

This study supports the theory that preeclampsia is a disorder in phospholipid metabolism in which malfunctioning of cellular membranes seems to play a major pathogenic role.

KEYWORDS:

31P and 1H-magnetic resonance spectroscopy; gestosis; lipid metabolism; preeclampsia

PMID:
23675281
PMCID:
PMC3615299
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