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Int J Biomed Sci. 2011 Dec;7(4):249-54.

A join point survival model for brain tumor patients.

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Department of Mathematics and Statistics, University of South Florida, USA;


To investigate the relationship between medical improvements and the survival experienced by the patient population, it would be useful to find out when and how much the cancer treatment breakthroughs and early diagnosis have significantly improved the prognosis of brain cancer patients. A join point model facilitates the identification of trends with significant change-points in survival; the main goal of such a model would be to find out when cancer survival starts exhibiting a pattern of improvement. The model will be applied to grouped relative survival data for major cancer sites from the 'Surveillance, epidemiology and end results' program of the National Cancer Institute.


Cox-PH; SEER; brain tumor; joinpoint; spline; survival


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