Format

Send to

Choose Destination
See comment in PubMed Commons below
Nanoscale. 2013 Jun 21;5(12):5506-13. doi: 10.1039/c3nr00549f.

Doped semiconductor nanocrystal based fluorescent cellular imaging probes.

Author information

1
Centre for Advanced Materials and Department of Materials Science, Indian Association for the Cultivation of Science, Kolkata, 700032, India.

Abstract

Doped semiconductor nanocrystals such as Mn doped ZnS, Mn doped ZnSe and Cu doped InZnS, are considered as new classes of fluorescent biological probes with low toxicity. Although the synthesis in high quality of such nanomaterials is now well established, transforming them into functional fluorescent probes remains a challenge. Here we report a fluorescent cellular imaging probe made of high quality doped semiconductor nanocrystals. We have identified two different coating approaches suitable for transforming the as synthesized hydrophobic doped semiconductor nanocrystals into water-soluble functional nanoparticles. Following these approaches we have synthesized TAT-peptide- and folate-functionalized nanoparticles of 10-80 nm hydrodynamic diameter and used them as a fluorescent cell label. The results shows that doped semiconductor nanocrystals can be an attractive alternative for conventional cadmium based quantum dots with low toxicity.

PMID:
23674276
DOI:
10.1039/c3nr00549f
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry
    Loading ...
    Support Center