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J Struct Funct Genomics. 2013 Jun;14(2):71-5. doi: 10.1007/s10969-013-9154-x. Epub 2013 May 15.

Crystal structure of AcrB complexed with linezolid at 3.5 Å resolution.

Author information

1
Los Alamos National Laboratory, Los Alamos, NM 87545, USA. lwhung@lanl.gov

Abstract

AcrB is an inner membrane resistance-nodulation-cell division efflux pump and is part of the AcrAB-TolC tripartite efflux system. We have determined the crystal structure of AcrB with bound Linezolid at a resolution of 3.5 Å. The structure shows that Linezolid binds to the A385/F386 loops of the symmetric trimer of AcrB. A conformational change of a loop in the bottom of the periplasmic cleft is also observed.

PMID:
23673416
PMCID:
PMC3679416
DOI:
10.1007/s10969-013-9154-x
[Indexed for MEDLINE]
Free PMC Article

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