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HPB (Oxford). 2014 Feb;16(2):109-18. doi: 10.1111/hpb.12117. Epub 2013 May 15.

Laparoscopic versus open liver resection: a meta-analysis of long-term outcome.

Author information

1
Department of Surgery, Jersey Shore University Medical Center; Department of Surgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Abstract

BACKGROUND:

Laparoscopic liver resection is growing in popularity, but the long-term outcome of patients undergoing laparoscopic liver resection for malignancy has not been established. This paper is a meta-analysis and compares the long-term survival of patients undergoing laparoscopic (LHep) versus open (OHep) liver resection for the treatment of malignant liver tumours.

METHODS:

A PubMed database search identified comparative human studies analysing LHep versus OHep for malignant tumours. Clinical and survival parameters were extracted. The search was last conducted on 18 March 2012.

RESULTS:

In total, 1002 patients in 15 studies were included (446 LHep and 556 OHep). A meta-analysis of overall survival showed no difference [1-year: odds ratio (OR) 0.71, 95% confidence interval (CI) 0.42 to 1.20, P = 0.202; 3-years: OR 0.76, 95% CI 0.56 to 1.03, P = 0.076; 5-years: OR 0.8, 95% CI 0.59 to 1.10, P = 0.173]. Subset analyses of hepatocellular carcinoma (HCC) and colorectal metastases (CRM) were performed. There was no difference in the 1-, 3-, and 5-year survival for HCC or in the 1-year survival for CRM, however, a survival advantage was found for CRM at 3 years (LHep 80% versus OHep 67.4%, P = 0.036).

CONCLUSIONS:

Laparoscopic surgery should be considered an acceptable alternative for the treatment of malignant liver tumours.

PMID:
23672270
PMCID:
PMC3921005
DOI:
10.1111/hpb.12117
[Indexed for MEDLINE]
Free PMC Article
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