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Horm Metab Res. 2013 Sep;45(9):646-51. doi: 10.1055/s-0033-1343472. Epub 2013 May 13.

Glucagon-like peptide-1 upregulates visfatin expression in 3T3-L1 adipocytes.

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1
Department of Endocrinology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai, China.

Abstract

The incretin hormone glucagon-like peptide-1 (GLP-1) exerts important functions in controlling glucose homeostasis. Many studies have revealed molecular targets of GLP-1, but its influence on adipokines has not been determined. Visfatin, a recently discovered adipokine, has been shown to attenuate insulin resistance by binding to insulin receptor. Our study shows that GLP-1 induced secretion of visfatin into the culture medium of 3T3-L1 adipocytes due to increased visfatin mRNA expression. Furthermore, the effect of GLP-1 on visfatin was dose- and time-dependent. H89, a protein kinase A inhibitor, prevented the induction of visfatin expression by GLP-1. Moreover, inhibition of NF-κB by PDTC reduced the basal visfatin release while having no effect on the transcription regulation by GLP-1. In addition, GLP-1 alleviated the decrease of visfatin mRNA expression under endoplasmic reticulum stress induced by thapsigargin. Taken together, our study suggests that GLP-1 promotes the novel insulin-mimetic adipocytokine visfatin expression via the PKA pathway and might influence glucose metabolism.

PMID:
23670349
DOI:
10.1055/s-0033-1343472
[Indexed for MEDLINE]
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