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FEBS Lett. 2013 Jun 19;587(12):1723-30. doi: 10.1016/j.febslet.2013.04.040. Epub 2013 May 10.

Physical interaction between calcineurin and Cav3.2 T-type Ca2+ channel modulates their functions.

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Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan.


Cav3.2 T-type Ca(2+) channel is required for the activation of calcineurin/NFAT signaling in cardiac hypertrophy. We aimed to investigate how Cav3.2 and calcineurin interact. We found that Ca(2+) and calmodulin modulate the Cav3.2/calcineurin interaction. Calcineurin binding to Cav3.2 decreases the enzyme's phosphatase activity and diminishes the channel's current density. Phenylephrine-induced hypertrophy in neonatal cardiac myocytes is reduced by a cell-permeable peptide with the calcineurin binding site sequence. These data suggest that Cav3.2 regulates calcineurin/NFAT pathway through both the Ca(2+) influx and calcineurin binding. Our findings unveiled a reciprocal regulation of Ca(2+) signaling which contributes to our understanding of cardiac hypertrophy.

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