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Cell Signal. 2013 Oct;25(10):1955-61. doi: 10.1016/j.cellsig.2013.04.009. Epub 2013 May 11.

Signaling networks of Rho GTPases in cell motility.

Author information

1
Department of Natural Science, The Lebanese American University, Beirut 1102 2801, Lebanon.

Abstract

The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In this review, we summarize the upstream and downstream players from Rho GTPases that are mainly involved in actin polymerization leading to cell motility and potentially playing a role in cancer cell metastasis.

KEYWORDS:

Actin; Cancer; Motility; PI3K; Rho GTPases

PMID:
23669310
DOI:
10.1016/j.cellsig.2013.04.009
[Indexed for MEDLINE]
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