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Appl Physiol Nutr Metab. 2013 May;38(5):533-6. doi: 10.1139/apnm-2012-0344. Epub 2012 Nov 21.

A study of DNA protective effect of orange juice supplementation.

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a Department of Applied Science, Hong Kong Institute of Vocational Education (Shatin), 21 Yuen Wo Road, Shatin, New Territories, Hong Kong; Macao Society for the Study of Women's Health, Macao.


The potential acute genoprotective effect of orange juice supplementation was investigated. Six healthy subjects (aged 33 to 60 years; 3 women and 3 men) were asked to drink 400 mL of commercial orange juice, which contained 100 mg vitamin C and 40.8 g sugar. Venous blood (2 mL) was taken before and 2 h after ingestion (test trial). A week later, the subjects were asked to repeat the trial by drinking 400 mL water with 100 mg vitamin C and 40.8 g glucose (control trial). Lymphocytes isolated from blood samples underwent comet assay on the day of collection. Pre- and postingestion DNA damage scores were measured in both the test and control trials. Results showed that there was a significant decrease in DNA damage induced by hydrogen peroxide after 2 h of supplementation with orange juice, and no change in baseline DNA damage. There was no significant decrease in the DNA damage in lymphocytes in the control trial.

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