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J Matern Fetal Neonatal Med. 2013 Dec;26(18):1765-7. doi: 10.3109/14767058.2013.804050. Epub 2013 Jul 24.

High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards.

Author information

1
Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University , East Lansing, MI , USA .

Abstract

OBJECTIVE:

To examine the correlation in genes expressed in paired umbilical cord blood (UCB) and newborn blood (NB).

METHOD:

Total mRNA and mRNA of three gene sets (inflammatory, hypoxia, and thyroidal response) was assessed using microarray in UCB and NB spotted on Guthrie cards from 7 mother/infant pairs.

RESULTS:

The average gene expression correlation between paired UCB and NB samples was 0.941 when all expressed genes were considered, and 0.949 for three selected gene sets.

CONCLUSION:

The high correlation of UCB and NB gene expression suggest that either source may be useful for examining gene expression in the perinatal period.

PMID:
23668672
PMCID:
PMC4048710
DOI:
10.3109/14767058.2013.804050
[Indexed for MEDLINE]
Free PMC Article
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