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Zhongguo Zhong Yao Za Zhi. 2013 Feb;38(3):314-7.

[Application and advance of artificial antigens in studies on allergic reaction of traditional Chinese medicine injections].

[Article in Chinese]

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Provincial-Ministerial Key Laboratory of Northern Medicine Foundation and Application Under Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, China.


There are some small molecules with potential allergenicity in traditional Chinese medicine injections. They are lack of immunogenicity due to their small molecular weight, but they can lead to allergic reactions when they were coupled with appropriate vectors. Therefore, how to couple small molecule semi-antigens with vectors to prepare complete antigens with immunogenicity and reactogenicity is the key for screening small molecular allergenic substances out of traditional Chinese medicine injections. In terms of semi-antigen characteristics of traditional Chinese medicine injections, vector selection and application, coupling method and complete antigen purification and identification, the author introduces the latest research situations of artificial antigen and antibody preparation technology, the advance in experimental studies on screening of allergenic substances in traditional Chinese medicine injections, as well as the application prospect of immuno-chip technology in studies on allergenic substances in traditional Chinese medicine injections, with the aim of providing new experimental thoughts and methods for safety control of traditional Chinese medicine injections.

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