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Nat Biotechnol. 2013 Jun;31(6):530-2. doi: 10.1038/nbt.2595. Epub 2013 May 12.

TALEN-mediated editing of the mouse Y chromosome.

Author information

1
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.

Abstract

The functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations. We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions and insertions in two Y-linked genes--Sry and Uty. TALEN-mediated gene editing is a useful tool for dissecting the biology of the Y chromosome.

PMID:
23666012
PMCID:
PMC3681814
DOI:
10.1038/nbt.2595
[Indexed for MEDLINE]
Free PMC Article

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