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Cancer Lett. 2013 Sep 1;337(2):248-53. doi: 10.1016/j.canlet.2013.05.003. Epub 2013 May 9.

Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection.

Author information

1
International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, The Second Military Medical University, Shanghai, PR China.

Abstract

The objective of the study was to investigate the clinical significance of CKAP4 in intrahepatic cholangiocellular carcinoma (ICC). CKAP4 expression was determined in a cohort containing 173 cases of ICC patients. We found that CKAP4 was overexpressed in the majority of ICC cases and was significantly associated with tumor size, distant metastasis, lymph node metastasis, UICC and TNM stage features. Kaplan-Meier and Cox regression data indicated that CKAP4 was correlated with favorable clinical outcome and was an independent predictor for overall survival (HR, 0.646; 95% CI, 0.463-0.900 [p=0.010]). Thus, CKAP4 may serve as a prognostic marker of ICC patients.

KEYWORDS:

CKAP4; Disease-free survival; Intrahepatic cholangiocellular carcinomas; Overall survival; Prognosis

PMID:
23665508
DOI:
10.1016/j.canlet.2013.05.003
[Indexed for MEDLINE]

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