Format

Send to

Choose Destination
Free Radic Biol Med. 2013 Sep;64:52-60. doi: 10.1016/j.freeradbiomed.2013.04.037. Epub 2013 May 9.

MicroRNA regulation of endothelial homeostasis and commitment-implications for vascular regeneration strategies using stem cell therapies.

Author information

1
Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, UK.

Abstract

Human embryonic (hESC) and induced pluripotent (hiPSC) stem cells have broad therapeutic potential in the treatment of a range of diseases, including those of the vascular system. Both hESCs and hiPSCs have the capacity for indefinite self-renewal, in addition to their ability to differentiate into any adult cell type. These cells could provide a potentially unlimited source of cells for transplantation and, therefore, provide novel treatments, e.g. in the production of endothelial cells for vascular regeneration. MicroRNAs are short, noncoding RNAs that act posttranscriptionally to control gene expression and thereby exert influence over a wide range of cellular processes, including maintenance of pluripotency and differentiation. Expression patterns of these small RNAs are tissue specific, and changes in microRNA levels have often been associated with disease states in humans, including vascular pathologies. Here, we review the roles of microRNAs in endothelial cell function and vascular disease, as well as their role in the differentiation of pluripotent stem cells to the vascular endothelial lineage. Furthermore, we discuss the therapeutic potential of stem cells and how knowledge and manipulation of microRNAs in stem cells may enhance their capacity for vascular regeneration.

KEYWORDS:

CVD; EC; EPC; Embryonic stem cells; Free radicals; Induced pluripotent stem cells; MicroRNA; Pluripotency; ROS; Regenerative medicine; VEGF; Vascular endothelial cells; cardiovascular disease; endothelial cell; endothelial progenitor cell; hESC; human embryonic stem cell; iPSC; induced pluripotent stem cell; mESC; miRNA; microRNA; murine embryonic stem cell; reactive oxygen species; vascular endothelial growth factor

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center